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Issue 8, 2013
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18F-barbiturates are PET tracers with diagnostic potential in Alzheimer's disease

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Abstract

Three fluoro-barbiturates were synthesised, showing in vivo sedative efficacy. One of them, [18F]1a, was synthesised in radiofluorinated form. PET/CT Imaging with [18F]1a identified β-amyloid over-expressing transgenic mice (βA mice) compared to wild type and tau lines. The fluorescent barbiturate 9 was able to label βA plaques in brain sections of βA mice, and co-localise with a fluorescent Zn(II) indicator.

Graphical abstract: 18F-barbiturates are PET tracers with diagnostic potential in Alzheimer's disease

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Publication details

The article was received on 18 Jul 2012, accepted on 04 Dec 2012 and first published on 04 Dec 2012


Article type: Communication
DOI: 10.1039/C2CC38443D
Citation: Chem. Commun., 2013,49, 792-794
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    18F-barbiturates are PET tracers with diagnostic potential in Alzheimer's disease

    E. Calamai, S. Dall'Angelo, D. Koss, J. Domarkas, T. J. McCarthy, M. Mingarelli, G. Riedel, L. F. Schweiger, A. Welch, B. Platt and M. Zanda, Chem. Commun., 2013, 49, 792
    DOI: 10.1039/C2CC38443D

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