Issue 8, 2013

18F-barbiturates are PET tracers with diagnostic potential in Alzheimer's disease

Abstract

Three fluoro-barbiturates were synthesised, showing in vivo sedative efficacy. One of them, [18F]1a, was synthesised in radiofluorinated form. PET/CT Imaging with [18F]1a identified β-amyloid over-expressing transgenic mice (βA mice) compared to wild type and tau lines. The fluorescent barbiturate 9 was able to label βA plaques in brain sections of βA mice, and co-localise with a fluorescent Zn(II) indicator.

Graphical abstract: 18F-barbiturates are PET tracers with diagnostic potential in Alzheimer's disease

Supplementary files

Article information

Article type
Communication
Submitted
18 Jul 2012
Accepted
04 Dec 2012
First published
04 Dec 2012

Chem. Commun., 2013,49, 792-794

18F-barbiturates are PET tracers with diagnostic potential in Alzheimer's disease

E. Calamai, S. Dall'Angelo, D. Koss, J. Domarkas, T. J. McCarthy, M. Mingarelli, G. Riedel, L. F. Schweiger, A. Welch, B. Platt and M. Zanda, Chem. Commun., 2013, 49, 792 DOI: 10.1039/C2CC38443D

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