A new class of NO-donor pro-drugs triggered by γ-glutamyl transpeptidase with potential for reno-selective vasodilatation

Qingzhi Zhang; Agnieszka Kulczynska; David J. Webb; Ian L. Megson; Nigel P. Botting

doi:10.1039/C2CC38382A

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Chemical Communications

Issue 14, 2013

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A new class of NO-donor pro-drugs triggered by γ-glutamyl transpeptidase with potential for reno-selective vasodilatation

Qingzhi Zhang,*^a Agnieszka Kulczynska,^a David J. Webb,^b Ian L. Megson*^c and Nigel P. Botting*^a

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University of St Andrews, EaStChem School of Chemistry and Centre for Biomolecular Sciences, North Haugh, St Andrews, UK
E-mail: qz@st-andrews.ac.uk ;
Fax: +44 (0)1334 463808 ;
Tel: +44 (0)1334 467274

Centre for Cardiovascular Science, The Queen's Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, Edinburgh, UK

Free Radical Research Facility, Department of Diabetes and Cardiovascular Science, The University of The Highlands & Islands, Centre for Health Science, Old Perth Road, Inverness, UK
E-mail: ian.megson@uhi.ac.uk ;
Fax: +44 (0)1463 711245 ;
Tel: +44 (0)1463 279562

Chem. Commun., 2013,49, 1389-1391

DOI: 10.1039/C2CC38382A
Received 21 Nov 2012, Accepted 20 Dec 2012
First published online 21 Dec 2012

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This communication describes the synthesis of a new class of N-hydroxyguanidine (NHG) pro-drugs which release nitric oxide (NO), triggered by the action of γ-glutamyl transpeptidase (γ-GT), and have potential for the treatment of acute renal injury/failure (ARI/ARF).

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Qingzhi Zhang
Agnieszka Kulczynska
David J. Webb
Ian L. Megson
Nigel P. Botting

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