Zn impacts Cu coordination to amyloid-β, the Alzheimer's peptide, but not the ROS production and the associated cell toxicity

Bruno Alies; Isabelle Sasaki; Olivier Proux; Stéphanie Sayen; Emmanuel Guillon; Peter Faller; Christelle Hureau

doi:10.1039/C2CC38236A

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Chemical Communications

Issue 12, 2013

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Zn impacts Cu coordination to amyloid-β, the Alzheimer's peptide, but not the ROS production and the associated cell toxicity

Bruno Alies,^a^b Isabelle Sasaki,^a^b Olivier Proux,^c Stéphanie Sayen,^d Emmanuel Guillon,^d Peter Faller*^a^b and Christelle Hureau*^a^b

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CNRS, LCC (Laboratoire de Chimie de Coordination), 205, route de Narbonne, F-31077 Toulouse, France

Université de Toulouse, UPS, INPT, LCC, F-31077 Toulouse, France
E-mail: christelle.hureau@lcc-toulouse.fr ;
Tel: +33 5 61 33 31 62

Observatoire des Sciences de l'Univers de Grenoble, CNRS and Université Joseph Fourier, BP 53, 38041 Grenoble Cedex 9, France

Institut de Chimie Moléculaire de Reims (ICMR, CNRS UMR 7312), Groupe de Chimie de Coordination, Université de Reims Champagne-Ardenne, BP 1039, 51687 Reims Cedex 2, France

Chem. Commun., 2013,49, 1214-1216

DOI: 10.1039/C2CC38236A
Received 15 Nov 2012, Accepted 12 Dec 2012
First published online 03 Jan 2013

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Combined coordination of Zn^II and Cu^I or Cu^II to the amyloid-β peptide has been investigated using XANES, EPR and NMR spectroscopies. While Zn^II does alter Cu^II binding to Aβ, this has no effect on (Aβ)Cu induced ROS production and associated cell toxicity.

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Bruno Alies
Isabelle Sasaki
Olivier Proux
Stéphanie Sayen
Emmanuel Guillon
Peter Faller
Christelle Hureau

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Zn impacts Cu coordination to amyloid-β, the Alzheimer's peptide, but not the ROS production and the associated cell toxicity

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