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Issue 13, 2013
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Femtomolar Zn(II) affinity of minimal zinc hook peptides – a promising small tag for protein engineering

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Abstract

The minimal zinc hook peptide of Rad50 and its alanine mutants form highly stable Zn(II) complexes. These peptides were successfully used as a small, efficient tag for reversible Zn(II)-mediated protein homodimerization. The high stability, its biological consequences and potential applications in protein engineering are discussed.

Graphical abstract: Femtomolar Zn(ii) affinity of minimal zinc hook peptides – a promising small tag for protein engineering

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Publication details

The article was received on 13 Nov 2012, accepted on 20 Dec 2012 and first published on 21 Dec 2012


Article type: Communication
DOI: 10.1039/C2CC38174E
Citation: Chem. Commun., 2013,49, 1312-1314
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    Femtomolar Zn(II) affinity of minimal zinc hook peptides – a promising small tag for protein engineering

    T. Kochańczyk, P. Jakimowicz and A. Krężel, Chem. Commun., 2013, 49, 1312
    DOI: 10.1039/C2CC38174E

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