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Issue 6, 2013
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Three-component access to pyrroles promoted by the CAN–silver nitrate system under high-speed vibration milling conditions: a generalization of the Hantzsch pyrrole synthesis

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Abstract

A sequential multicomponent process involving the high-speed vibration milling of ketones with N-iodosuccinimide and p-toluenesulfonic acid, followed by addition of a mixture of primary amines, β-dicarbonyl compounds, cerium(IV) ammonium nitrate and silver nitrate afforded polysubstituted, functionalized pyrroles. This one-pot, solid-state process can be considered as the coupling of an α-iodoketone preparation with a general version of the classical Hantzsch pyrrole synthesis.

Graphical abstract: Three-component access to pyrroles promoted by the CAN–silver nitrate system under high-speed vibration milling conditions: a generalization of the Hantzsch pyrrole synthesis

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Publication details

The article was received on 08 Nov 2012, accepted on 26 Nov 2012 and first published on 27 Nov 2012


Article type: Communication
DOI: 10.1039/C2CC38099D
Citation: Chem. Commun., 2013,49, 591-593
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    Three-component access to pyrroles promoted by the CAN–silver nitrate system under high-speed vibration milling conditions: a generalization of the Hantzsch pyrrole synthesis

    V. Estévez, M. Villacampa and J. C. Menéndez, Chem. Commun., 2013, 49, 591
    DOI: 10.1039/C2CC38099D

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