Issue 9, 2013

Catalytic highly enantioselective vinylogous Povarov reaction

Abstract

The first example of a catalytic asymmetric vinylogous Povarov reaction is presented. 1-N-Acylamino-1,3-butadienes react selectively at their terminal double bond in the presence of a chiral phosphoric acid catalyst, delivering highly enantioenriched 1,2,3,4-tetrahydroquinolines bearing a synthetically versatile enecarbamate group at the 4-position.

Graphical abstract: Catalytic highly enantioselective vinylogous Povarov reaction

Supplementary files

Article information

Article type
Communication
Submitted
05 Nov 2012
Accepted
06 Dec 2012
First published
07 Dec 2012

Chem. Commun., 2013,49, 880-882

Catalytic highly enantioselective vinylogous Povarov reaction

L. Caruana, M. Fochi, S. Ranieri, A. Mazzanti and L. Bernardi, Chem. Commun., 2013, 49, 880 DOI: 10.1039/C2CC38002A

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