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Indian Association for the Cultivation of Science, Department of Inorganic Chemistry, 2A & 2B, Raja S. C.Mullick Road, Jadavpur, Kolkata, India
; Fax: +91 33 2473-2805/2483-656
Chem. Commun., 2013,49, 1091-1093
19 Oct 2012,
12 Dec 2012
First published online
14 Dec 2012
Redox active metals (Fe and Cu) and cofactors (heme) bind to Aβ peptides and react with O2 in their reduced state leading to oxidative stress in the brain. In this study we cryogenically trap and characterize a Fe–O2 intermediate, using resonance Raman spectroscopy, involved in reactive oxygen species formation by Aβ peptides. This is the first reaction intermediate relevant to Alzheimer's disease to be reported.
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