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Issue 5, 2013
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Branched DNA nanostructures efficiently stabilised and monitored by novel pyrene–perylene 2′-α-L-amino-LNA FRET pairs

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Abstract

Novel pyreneperylene α-L-LNA FRET pairs described herein effectively detect assembly of 2- and 3-way branched DNA nanostructures prepared by postsynthetic microwave-assisted CuAAC click chemistry. The fluorescent signalling of assembly by internally positioned FRET pairs is achieved with low to no fluorescence background signal, remarkably low limit of target detection values and stabilization of the resulting nanostructures.

Graphical abstract: Branched DNA nanostructures efficiently stabilised and monitored by novel pyrene–perylene 2′-α-l-amino-LNA FRET pairs

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Publication details

The article was received on 16 Oct 2012, accepted on 19 Nov 2012 and first published on 20 Nov 2012


Article type: Communication
DOI: 10.1039/C2CC37547H
Citation: Chem. Commun., 2013,49, 511-513
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    Branched DNA nanostructures efficiently stabilised and monitored by novel pyrene–perylene 2′-α-L-amino-LNA FRET pairs

    I. K. Astakhova, T. Santhosh Kumar, M. A. Campbell, A. V. Ustinov, V. A. Korshun and J. Wengel, Chem. Commun., 2013, 49, 511
    DOI: 10.1039/C2CC37547H

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