Small neutral molecular carriers for selective carboxylate transport

Cally J. E. Haynes; Stuart N. Berry; Joachim Garric; Julie Herniman; Jennifer R. Hiscock; Isabelle L. Kirby; Mark E. Light; Gregory Perkes; Philip A. Gale

doi:10.1039/C2CC37468D

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Chemical Communications

Issue 3, 2013

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Small neutral molecular carriers for selective carboxylate transport

Cally J. E. Haynes,^a Stuart N. Berry,^a Joachim Garric,^a Julie Herniman,^a Jennifer R. Hiscock,^a Isabelle L. Kirby,^a Mark E. Light,^a Gregory Perkes^a and Philip A. Gale*^a

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Chemistry, University of Southampton, Southampton SO17 1BJ, UK
E-mail: philip.gale@soton.ac.uk ;
Fax: +44 (0)23 8059 6805 ;
Tel: +44 (0)23 8059 3332

Chem. Commun., 2013,49, 246-248

DOI: 10.1039/C2CC37468D
Received 12 Oct 2012, Accepted 14 Nov 2012
First published online 23 Nov 2012

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A series of neutral thiourea receptors were found to mediate the antiport of chloride with a range of biologically relevant carboxylate anions across phospholipid bilayers. Simple structural modification of the carriers resulted in a change in the lactate/pyruvate transport selectivity.

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Cally J. E. Haynes
Stuart N. Berry
Joachim Garric
Julie Herniman
Jennifer R. Hiscock
Isabelle L. Kirby
Mark E. Light
Gregory Perkes
Philip A. Gale

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Small neutral molecular carriers for selective carboxylate transport

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