This communication describes a chiral base-catalyzed asymmetric [1,3]-proton shift of trifluoromethyl ketimines, giving a wide variety of trifluoromethyl aldimines containing various functional groups with up to 94% ee.
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An efficient synthesis of optically active trifluoromethyl aldimines via asymmetric biomimetic transamination
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a
Beijing National Laboratory of Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
b
Department of Chemistry, Colorado State University, Fort Collins, USA.
E-mail: yian@lamar.colostate.edu ;
Fax: 001-970-4911801 ;
Tel: 001-970-4917424
E-mail: yian@lamar.colostate.edu ;
Fax: 001-970-4911801 ;
Tel: 001-970-4917424
Chem. Commun., 2013,49, 1404-1406
DOI: 10.1039/C2CC37423D
Received 11 Oct 2012, Accepted 17 Dec 2012
First published online 21 Dec 2012
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