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Issue 13, 2013
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Targeting cancer cells with controlled release nanocapsules based on a single aptamer

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Abstract

Molecular gates have received considerable attention as drug delivery systems. More recently, aptamer-based gates showed great potential in overcoming major challenges associated with drug delivery by means of nanocapsules. Based on a switchable aptamer nanovalves approach, we herein report the first demonstration of an engineered single molecular gate that directs nanoparticles to cancer cells and subsequently delivers the payload in a controllable fashion.

Graphical abstract: Targeting cancer cells with controlled release nanocapsules based on a single aptamer

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Publication details

The article was received on 09 Oct 2012, accepted on 20 Dec 2012 and first published on 21 Dec 2012


Article type: Communication
DOI: 10.1039/C2CC37370J
Citation: Chem. Commun., 2013,49, 1285-1287
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    Targeting cancer cells with controlled release nanocapsules based on a single aptamer

    F. J. Hernandez, L. I. Hernandez, A. Pinto, T. Schäfer and V. C. Özalp, Chem. Commun., 2013, 49, 1285
    DOI: 10.1039/C2CC37370J

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