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KTH Royal Institute of Technology, Division of Biochemistry, School of Biotechnology, AlbaNova University Center, SE-106 91 Stockholm, Sweden
E-mail: per.berglund@biotech.kth.se
; Fax: +46 8 5537 8468
; Tel: +46 8 5537 8366
Chem. Commun., 2013,49, 161-163
DOI:
10.1039/C2CC37232K
Received
03 Oct 2012,
Accepted
07 Nov 2012
First published online
08 Nov 2012
An efficient single-enzymatic cascade approach for the asymmetric synthesis of chiral amines has been developed, which applies the amino donor 3-aminocyclohexa-1,5-dienecarboxylic acid spontaneously tautomerizing to reach reaction completion with excellent ee values.