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Issue 39, 2013
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Intracellular nitric oxide delivery from stable NO-polymeric nanoparticle carriers

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Abstract

The encapsulation of S-nitrosoglutathione into polymeric nanoparticles substantially improves NO stability in aqueous media without affecting the efficacy of intracellular delivery. The combination of nano-NO delivery and chemotherapy has been found to enhance antitumour activity of chemotherapeutics, as demonstrated using preliminary in vitro experiments with neuroblastoma cells.

Graphical abstract: Intracellular nitric oxide delivery from stable NO-polymeric nanoparticle carriers

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Publication details

The article was received on 02 Oct 2012, accepted on 25 Oct 2012 and first published on 16 Nov 2012


Article type: Communication
DOI: 10.1039/C2CC37181B
Citation: Chem. Commun., 2013,49, 4190-4192
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    Intracellular nitric oxide delivery from stable NO-polymeric nanoparticle carriers

    H. T. T. Duong, Z. M. Kamarudin, R. B. Erlich, Y. Li, M. W. Jones, M. Kavallaris, C. Boyer and T. P. Davis, Chem. Commun., 2013, 49, 4190
    DOI: 10.1039/C2CC37181B

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