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Issue 4, 2013
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Controlling the function of DNA nanostructures with specific trigger sequences

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Abstract

We report a hybridization-based switching mechanism with single-base specificity that can be readily integrated with functional DNA nanostructures. As an exemplar, we have developed a switchable DNAzyme (SDZ) that only becomes activated in the presence of a perfectly matched trigger sequence and operates effectively at room temperature.

Graphical abstract: Controlling the function of DNA nanostructures with specific trigger sequences

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Publication details

The article was received on 21 Sep 2012, accepted on 13 Nov 2012 and first published on 28 Nov 2012


Article type: Communication
DOI: 10.1039/C2CC36878A
Citation: Chem. Commun., 2013,49, 397-399
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    Controlling the function of DNA nanostructures with specific trigger sequences

    S. Deborggraeve, J. Y. Dai, Y. Xiao and H. T. Soh, Chem. Commun., 2013, 49, 397
    DOI: 10.1039/C2CC36878A

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