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Issue 2, 2013
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An immobilized and reusable Cu(I) catalyst for metal ion-free conjugation of ligands to fully deprotected oligonucleotides through click reaction

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Abstract

Chelation of Cu(I) ions to an immobilized hydrophilic tris(triazolylmethyl)amine chelator on a solid support allowed synthesis of RNA oligonucleotide conjugates from completely deprotected alkyne-oligonucleotides. No oligonucleotide strand degradation or metal ion contamination was observed. Furthermore, use of the immobilized copper(I) ion overcame regioselectivity issues associated with strain-promoted copper-free azide–alkyne cycloaddition.

Graphical abstract: An immobilized and reusable Cu(i) catalyst for metal ion-free conjugation of ligands to fully deprotected oligonucleotides through click reaction

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Publication details

The article was received on 18 Sep 2012, accepted on 05 Nov 2012 and first published on 21 Nov 2012


Article type: Communication
DOI: 10.1039/C2CC36811K
Citation: Chem. Commun., 2013,49, 184-186
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    An immobilized and reusable Cu(I) catalyst for metal ion-free conjugation of ligands to fully deprotected oligonucleotides through click reaction

    L. Eltepu, M. Jayaraman, K. G. Rajeev and M. Manoharan, Chem. Commun., 2013, 49, 184
    DOI: 10.1039/C2CC36811K

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