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Department of Chemistry, Texas Christian University, 2800 S. University, Ft. Worth, USA
E-mail: kayla.green@tcu.edu
; Fax: +1 817 257 5851
; Tel: +1 817 257 6220
b
Institute for Aging and Alzheimer's Disease Research, Department of Pharmacology & Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie, Ft. Worth, USA
E-mail: james.simpkins@unthsc.edu
; Fax: +1 817 735 2091
; Tel: +1 817 735 0498
Chem. Commun., 2013,49, 2712-2714
DOI:
10.1039/C2CC36808K
Received
31 Aug 2012,
Accepted
17 Dec 2012
First published online
25 Feb 2013
Metal-ion misregulation and oxidative stress have been linked to the progressive neurological decline associated with multiple neurodegenerative disorders. Transition metal-mediated oxidation of biomolecules via Fenton chemical reactions plays a role in disease progression. Herein we report the synthesis, characterization and antioxidant activity of 2; a pyclen derivative with enhanced antioxidant character.
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