Hyaluronated fullerenes with photoluminescent and antitumoral activity

Dong Sup Kwag; Kyeongsoon Park; Kyung Taek Oh; Eun Seong Lee

doi:10.1039/C2CC36596K

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Chemical Communications

Issue 3, 2013

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Hyaluronated fullerenes with photoluminescent and antitumoral activity

Dong Sup Kwag,^a Kyeongsoon Park,^b Kyung Taek Oh^c and Eun Seong Lee*^a

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Division of Biotechnology, The Catholic University of Korea, 43-1, Yeokgok 2-dong, Wonmi-gu, Bucheon, Republic of Korea
E-mail: eslee@catholic.ac.kr

Division of Biological Imaging, Chuncheon Center, Korea Basic Science Institute, Chuncheon 200-701, Republic of Korea

College of Pharmacy, Chung-Ang University, 221 Heukseok dong, Dongjak-gu, Republic of Korea

Chem. Commun., 2013,49, 282-284

DOI: 10.1039/C2CC36596K
Received 11 Sep 2012, Accepted 13 Nov 2012
First published online 14 Nov 2012

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Hyaluronated fullerene has strong near-infrared (NIR) fluorescence intensity without labelling with any fluorophores or isotopes. This fullerene allowed high-resolution fluorescent imaging of tumor sites in vivo and resulted in a significant regression of HCT-116 tumors.

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