Jump to main content
Jump to site search

Issue 26, 2013
Previous Article Next Article

Copper-catalyzed trifluoromethylation of aryl- and vinylboronic acids with generation of CF3-radicals

Author affiliations

Abstract

The selective trifluoromethylation of aryl- and vinylboronic acids proceeds smoothly with CF3SO2Na (Langlois reagent) in the presence of copper catalysts and t-BuOOH. Therefore, the method relies both on transition metal catalysis and selective radical reactions. Advantageously, the protocol can be performed at room temperature under an air atmosphere and avoids the issue of poor regioselectivity.

Graphical abstract: Copper-catalyzed trifluoromethylation of aryl- and vinylboronic acids with generation of CF3-radicals

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 09 Sep 2012, accepted on 17 Dec 2012 and first published on 17 Dec 2012


Article type: Communication
DOI: 10.1039/C2CC36554E
Citation: Chem. Commun., 2013,49, 2628-2630
  •   Request permissions

    Copper-catalyzed trifluoromethylation of aryl- and vinylboronic acids with generation of CF3-radicals

    Y. Li, L. Wu, H. Neumann and M. Beller, Chem. Commun., 2013, 49, 2628
    DOI: 10.1039/C2CC36554E

Search articles by author