Issue 39, 2013

PNA-based microRNA inhibitors elicit anti-inflammatory effects in microglia cells

Abstract

Peptide nucleic acid (PNA) inhibitors of miR-221-3p (CU-PNA-221) and miR-466l-3p (CU-PNA-466) demonstrated changes in inflammatory responses. Suppression of inflammatory signalling was unexpected and further investigation led to the identification of calmodulin as a novel target of miRNA-466l-3p. These studies demonstrate that exogenous agents may suppress neuroinflammation mediated by microglial cells.

Graphical abstract: PNA-based microRNA inhibitors elicit anti-inflammatory effects in microglia cells

Supplementary files

Article information

Article type
Communication
Submitted
24 Jul 2012
Accepted
19 Oct 2012
First published
22 Oct 2012

Chem. Commun., 2013,49, 4415-4417

PNA-based microRNA inhibitors elicit anti-inflammatory effects in microglia cells

P. N. Brown and H. Yin, Chem. Commun., 2013, 49, 4415 DOI: 10.1039/C2CC36540E

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