Through substituting two canonical base pairs of a streptavidin-binding aptamer with T–T mismatched base pairs, a new aptamer was constructed. Its binding ability could be controlled by Hg2+ through the formation of T–Hg–T metal–base pairs.
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Rational design of Hg2+ controlled streptavidin-binding aptamer
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a
Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China
E-mail: sgdh@iccas.ac.cn ;
Fax: +86-10-62528509 ;
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E-mail: sgdh@iccas.ac.cn ;
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Tel: +86-10-62528509
b
Graduate School of the Chinese Academy of Sciences, Beijing, China
Chem. Commun., 2013,49, 164-166
DOI: 10.1039/C2CC36416F
Received 03 Sep 2012, Accepted 07 Nov 2012
First published online 08 Nov 2012
Chemical Communications
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