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Issue 3, 2013
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Bioinspired catalytic nitrile hydration by dithiolato, sulfinato/thiolato, and sulfenato/sulfinato ruthenium complexes

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Abstract

A series of Ru(II) catalysts inspired by the metalloenzyme nitrile hydratase catalyze the hydration of benzonitrile with up to 242 turnovers under neutral conditions with very low catalysts loading. Catalysts with an oxidized sulfur environment are less susceptible to product inhibition increasing the catalytic efficiency at low nitrile : water ratios.

Graphical abstract: Bioinspired catalytic nitrile hydration by dithiolato, sulfinato/thiolato, and sulfenato/sulfinato ruthenium complexes

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Publication details

The article was received on 20 Jul 2012, accepted on 14 Nov 2012 and first published on 16 Nov 2012


Article type: Communication
DOI: 10.1039/C2CC35256G
Citation: Chem. Commun., 2013,49, 294-296
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    Bioinspired catalytic nitrile hydration by dithiolato, sulfinato/thiolato, and sulfenato/sulfinato ruthenium complexes

    D. Kumar, C. A. Masitas, T. N. Nguyen and C. A. Grapperhaus, Chem. Commun., 2013, 49, 294
    DOI: 10.1039/C2CC35256G

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