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Issue 10, 2013
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Nucleic acid-directed self-assembly of multifunctional gold nanoparticle imaging agents

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Abstract

Gold nanoparticles have attracted much interest as a platform for development of multifunctional imaging and therapeutic agents. Multifunctionalized gold nanoparticles are generally constructed by covalent assembly of a gold core with thiolated ligands. In this study, we have assembled multifunctionalized gold nanoparticles in one step by nucleic acid hybridization of ODN (oligodeoxynucleotide)-derivatized gold nanoparticles with a library of pre-functionalized complementary PNAs (peptide nucleic acids). The PNAs were functionalized by conjugation with DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) for chelating 64Cu for PET imaging, PEG (polyethylene glycol) for conferring stealth properties, and Cy5 for fluorescent imaging. The resulting nanoparticles showed good stability in vitro by melting temperature studies, and in vivo by showing biodistribution behavior in a mouse that would be expected for a PEGylated gold nanoparticle rather than that for the radiolabelled PNA used in its assembly.

Graphical abstract: Nucleic acid-directed self-assembly of multifunctional gold nanoparticle imaging agents

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Publication details

The article was received on 13 Mar 2013, accepted on 04 Jun 2013 and first published on 20 Jun 2013


Article type: Paper
DOI: 10.1039/C3BM60070J
Citation: Biomater. Sci., 2013,1, 1055-1064
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    Nucleic acid-directed self-assembly of multifunctional gold nanoparticle imaging agents

    Z. Zhang, Y. Liu, C. Jarreau, M. J. Welch and J. A. Taylor, Biomater. Sci., 2013, 1, 1055
    DOI: 10.1039/C3BM60070J

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