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Issue 8, 2013
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Comparison of various sampling schemes and accumulation profiles in covariance spectroscopy with exponentially decaying 2D signals

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Abstract

Two-dimensional covariance (COV2D) spectroscopy offers an alternative approach to 2D Fourier transformation (FT2D) to obtain homo-nuclear correlation NMR spectra. Considerable saving in experimental time, without loss of resolution, can be achieved by incorporating COV2D with: (i) uniform sampling with a t1 cut-off (CUO) or non-uniform sampling (NUS), and (ii) constant or Gaussian accumulation profiles. We find that covariance treatment, combined with the CUO sampling and Gaussian accumulation profile provides better gain in experimental time, with respect to that required with FT2D NMR. This is in contrast with the maximum entropy (MaxEnt) reconstruction for 2D spectra, which works better with the NUS scheme rather than with the CUO scheme. We further discuss the experimental conditions that define this optimum acquisition, and explain how these parameters can easily be optimized ‘on the fly’ according to the desired resolution, which is quite sample-dependent.

Graphical abstract: Comparison of various sampling schemes and accumulation profiles in covariance spectroscopy with exponentially decaying 2D signals

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Publication details

The article was received on 24 Sep 2012, accepted on 06 Feb 2013 and first published on 07 Feb 2013


Article type: Paper
DOI: 10.1039/C3AN36375A
Citation: Analyst, 2013,138, 2411-2419
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    Comparison of various sampling schemes and accumulation profiles in covariance spectroscopy with exponentially decaying 2D signals

    Y. Li, B. Hu, Q. Chen, Q. Wang, Z. Zhang, J. Yang, I. Noda, J. Trébosc, O. Lafon, J. Amoureux and F. Deng, Analyst, 2013, 138, 2411
    DOI: 10.1039/C3AN36375A

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