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Issue 19, 2013
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Tyrosine-functionalized CuInS2 quantum dots as a fluorescence probe for the determination of biothiols, histidine and threonine

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Abstract

A novel, rapid and highly sensitive fluorescence turn-on assay for the detection of biothiols (glutathione, and L-cysteine), histidine and threonine was developed. Water-soluble CuInS2 ternary quantum dots (QDs) capped by mercaptopropionic acid (MPA) were directly synthesized in aqueous solution, and then functionalized using tyrosine molecules to form tyrosine-functionalized CuInS2 QDs (T-CuInS2 QDs). The fluorescence of T-CuInS2 QDs would decrease in the presence of Cu2+ due to the coordination effect of phenolic hydroxyls of the tyrosine molecules. Subsequently, the addition of biothiols (glutathione and L-cysteine), histidine or threonine could turn on the fluorescence of the T-CuInS2 QDs–Cu2+ system due to their strong affinity for Cu2+. The proposed method was simple in design and fast in operation, and it was applied for the detection of glutathione, L-cysteine, histidine, and threonine in human serum samples with satisfactory results.

Graphical abstract: Tyrosine-functionalized CuInS2 quantum dots as a fluorescence probe for the determination of biothiols, histidine and threonine

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Publication details

The article was received on 16 Apr 2013, accepted on 12 Jul 2013 and first published on 12 Jul 2013


Article type: Paper
DOI: 10.1039/C3AN00758H
Citation: Analyst, 2013,138, 5819-5825
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    Tyrosine-functionalized CuInS2 quantum dots as a fluorescence probe for the determination of biothiols, histidine and threonine

    S. Liu, F. Shi, L. Chen and X. Su, Analyst, 2013, 138, 5819
    DOI: 10.1039/C3AN00758H

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