Jump to main content
Jump to site search

Issue 14, 2013
Previous Article Next Article

Change in the microenvironment of breast cancer studied by FTIR imaging

Author affiliations

Abstract

Fourier transform infrared (FTIR) imaging was applied on histopathological specimens of breast cancer of different tumor histological grades. Focus was given to the extracellular matrix. FTIR spectral changes were observed when examining the extracellular matrix close to and far from carcinoma. Major changes were observed, in particular in the relative intensities of the collagen bands at 1640 and 1630 cm−1. PCA analysis and global fitting indicate a continuous progression in collagen spectral features when moving away from the tumor. These preliminary results suggest FTIR spectral features present in the 1700–1600 cm−1 spectral range could be used as spectral markers to identify cancer-induced modifications in collagen. This chemical imaging approach to analyze the breast cancer microenvironment could be used in the future for improving diagnostics of breast cancer.

Graphical abstract: Change in the microenvironment of breast cancer studied by FTIR imaging

Back to tab navigation

Supplementary files

Publication details

The article was received on 31 Jan 2013, accepted on 08 Apr 2013 and first published on 08 Apr 2013


Article type: Paper
DOI: 10.1039/C3AN00241A
Citation: Analyst, 2013,138, 4058-4065
  •   Request permissions

    Change in the microenvironment of breast cancer studied by FTIR imaging

    S. Kumar, C. Desmedt, D. Larsimont, C. Sotiriou and E. Goormaghtigh, Analyst, 2013, 138, 4058
    DOI: 10.1039/C3AN00241A

Search articles by author

Spotlight

Advertisements