Jump to main content
Jump to site search

Issue 8, 2013
Previous Article Next Article

Intraoperative detection of liver tumors aided by a fluorescence goggle system and multimodal imaging

Author affiliations

Abstract

Real-time image guidance in the operating room is needed to improve instantaneous surgical decisions. Toward this goal, we utilized a new fluorescence goggle system and a near-infrared fluorescent dye approved for human use, indocyanine green, to demonstrate the feasibility of detecting liver tumors intraoperatively. The fluorescence goggle provided successful imaging of multifocal breast cancer metastases in mouse liver. Diffused tumor deposits as small as 0.8 mm in diameter were detected, which were not obvious without the fluorescence goggle. A combination of surface-weighted fluorescence imaging and deep tissue-sensitive ultrasound imaging allowed comprehensive image guidance with the fluorescence goggle system for tumor resection in a rabbit VX2 liver metastasis model. This multimodal detection and guided surgical intervention strategy using ultrasonic imaging and real-time intraoperative fluorescence guidance is a promising and innovative technology platform for improving surgical outcome of human patients with primary or metastatic liver cancer.

Graphical abstract: Intraoperative detection of liver tumors aided by a fluorescence goggle system and multimodal imaging

Back to tab navigation

Supplementary files

Publication details

The article was received on 22 Jan 2013, accepted on 25 Feb 2013 and first published on 25 Feb 2013


Article type: Communication
DOI: 10.1039/C3AN00165B
Citation: Analyst, 2013,138, 2254-2257
  •   Request permissions

    Intraoperative detection of liver tumors aided by a fluorescence goggle system and multimodal imaging

    Y. Liu, W. J. Akers, A. Q. Bauer, S. Mondal, K. Gullicksrud, G. P. Sudlow, J. P. Culver and S. Achilefu, Analyst, 2013, 138, 2254
    DOI: 10.1039/C3AN00165B

Search articles by author

Spotlight

Advertisements