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Issue 12, 2013
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Biological and biomedical 14C-accelerator mass spectrometry and graphitization of carbonaceous samples

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Abstract

Accelerator mass spectrometry (AMS) is the ultimate technique for measuring rare isotopes in small samples. Biological and biomedical applications of 14C-AMS (bio-14C-AMS) commenced in the early 1990s and are now widely used in many research fields including pharmacology, toxicology, food, and nutrition. For accurate, precise, and reproducible bio-14C-AMS analysis, the graphitization step in sample preparation is the most critical step. So, various sample preparation methods for a process called graphitization have been reported for specific applications. Catalytic graphitization using either a flame-sealed borosilicate tube or a septa-sealed vial is a popular sample preparation method for bio-14C-AMS. In this review, we introduce the AMS system, especially for bio-14C-AMS. In addition, we also review the graphitization method for bio-14C-AMS to promote further understanding and improvement of sample preparation for this technique. Examples of catalytic graphitization methods over the past two decades are described.

Graphical abstract: Biological and biomedical 14C-accelerator mass spectrometry and graphitization of carbonaceous samples

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Publication details

The article was received on 10 Jan 2013, accepted on 07 Apr 2013 and first published on 08 Apr 2013


Article type: Tutorial Review
DOI: 10.1039/C3AN00077J
Citation: Analyst, 2013,138, 3347-3355
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    Biological and biomedical 14C-accelerator mass spectrometry and graphitization of carbonaceous samples

    I. Chung and S. Kim, Analyst, 2013, 138, 3347
    DOI: 10.1039/C3AN00077J

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