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Issue 5, 2013
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Adsorptive stripping voltammetric determination of imipramine, trimipramine and desipramine employing titanium dioxide nanoparticles and an Amberlite XAD-2 modified glassy carbon paste electrode

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Abstract

An Amberlite XAD-2 (XAD2) and titanium dioxide nanoparticles (TNPs) modified glassy carbon paste electrode (XAD2-TNP-GCPE) was developed for the determination of imipramine (IMI), trimipramine (TRI) and desipramine (DES). The electrochemical behavior of these molecules was investigated employing cyclic voltammetry (CV), chronocoulometry (CC), electrochemical impedance spectroscopy (EIS) and adsorptive stripping differential pulse voltammetry (AdSDPV). After optimization of analytical conditions using a XAD2-TNP-GCPE electrode at pH 6.0 phosphate buffer (0.1 M), the peak currents were found to vary linearly with its concentration in the range of 1.30 × 10−9 to 6.23 × 10−6 M for IMI, 1.16 × 10−9 to 6.87 × 10−6 M for TRI and 1.43 × 10−9 to 5.68 × 10−6 M for DES. The detection limits (S/N = 3) of 3.93 × 10−10, 3.51 × 10−10 and 4.35 × 10−10 M were obtained for IMI, TRI and DES respectively using AdSDPV. The prepared modified electrode showed several advantages such as a simple preparation method, high sensitivity, very low detection limits and excellent reproducibility. The proposed method was employed for the determination of IMI, TRI and DES in pharmaceutical formulations, blood serum and urine samples.

Graphical abstract: Adsorptive stripping voltammetric determination of imipramine, trimipramine and desipramine employing titanium dioxide nanoparticles and an Amberlite XAD-2 modified glassy carbon paste electrode

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Publication details

The article was received on 16 Sep 2012, accepted on 03 Jan 2013 and first published on 07 Jan 2013


Article type: Paper
DOI: 10.1039/C2AN36330E
Citation: Analyst, 2013,138, 1395-1404
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    Adsorptive stripping voltammetric determination of imipramine, trimipramine and desipramine employing titanium dioxide nanoparticles and an Amberlite XAD-2 modified glassy carbon paste electrode

    B. J. Sanghavi and A. K. Srivastava, Analyst, 2013, 138, 1395
    DOI: 10.1039/C2AN36330E

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