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Issue 3, 2013
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Coupling isotachophoresis and capillary electrophoresis: a review and comparison of methods

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Abstract

We present a comprehensive review and comparison of the methodologies for increasing sensitivity and resolution of capillary electrophoresis (CE) using online transient isotachophoresis (tITP). We categorize the diverse set of coupled tITP and CE (tITP-CE) methods based on their fundamental principles for disrupting isotachophoretic preconcentration and triggering electrophoretic separation. Based on this classification, we discuss important features, advantages, limitations, and optimization principles of various tITP-CE methods. We substantiate our discussion with original simulations, instructive examples, and published experimental results.

Graphical abstract: Coupling isotachophoresis and capillary electrophoresis: a review and comparison of methods

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Publication details

The article was received on 17 Aug 2012, accepted on 21 Nov 2012 and first published on 22 Nov 2012


Article type: Tutorial Review
DOI: 10.1039/C2AN36150G
Citation: Analyst, 2013,138, 735-754
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    Coupling isotachophoresis and capillary electrophoresis: a review and comparison of methods

    S. S. Bahga and J. G. Santiago, Analyst, 2013, 138, 735
    DOI: 10.1039/C2AN36150G

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