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Issue 40, 2012
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Mechano-responsive hydrogels crosslinked by block copolymer micelles

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Abstract

Block copolymer micelles (BCMs) were prepared from amphiphilic diblock copolymers of poly(n-butyl acrylate) and poly(acrylic acid) partially modified with 2-hydroxyethyl acrylate. Radical polymerization of acrylamide in the presence of micellar crosslinkers gave rise to elastomeric hydrogels (BCM-PAAm) whose mechanical properties can be tuned by varying the BCM composition. Transmission electron microscopy (TEM) imaging revealed stretch-induced, reversible micelle deformation in BCM-PAAm gels. A model hydrophobic drug, pyrene, loaded into the micelle core prior to the formation of BCM-PAAm gels, was dynamically released in response to externally applied mechanical forces. The BCM-crosslinked hydrogels with combined strength and force-modulated drug release are attractive candidates for the repair and regeneration of mechanically active tissues.

Graphical abstract: Mechano-responsive hydrogels crosslinked by block copolymer micelles

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Publication details

The article was received on 05 Jul 2012, accepted on 07 Aug 2012 and first published on 30 Aug 2012


Article type: Communication
DOI: 10.1039/C2SM26566D
Citation: Soft Matter, 2012,8, 10233-10237
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    Mechano-responsive hydrogels crosslinked by block copolymer micelles

    L. Xiao, J. Zhu, J. D. Londono, D. J. Pochan and X. Jia, Soft Matter, 2012, 8, 10233
    DOI: 10.1039/C2SM26566D

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