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Issue 28, 2012
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Reduction-responsive shell-crosslinked micelles prepared from Y-shaped amphiphilic block copolymers as a drug carrier

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Abstract

Biodegradable Y-shaped amphiphilic block copolymer mPEG-b-PLG-b-(PLA)2 was synthesized and characterized by 1H NMR and FTIR. The amphiphilic property of the copolymer with a mPEG-b-PLG segment as the hydrophilic arm and two PLA segments as the hydrophobic arms endows the copolymer with the ability to form core–shell nanoparticles in aqueous solution. Co-assembly of doxorubicin (Dox) and the block copolymer in selective solvent was carried out to prepare Dox-loaded micelles. The inner-shell (PLG) of the micelle was crosslinked through a carbodiimide coupling method with cystamine as the crosslinker. The crosslinked micelles exhibit reduction-responsive release of Dox and the stability in vitro was much better than non-crosslinked micelles. In acidic release condition, the total amount of Dox released could be increased due to the increased solubility of Dox. The blood clearance of Dox in different form of micelles was studied and the results show that Dox loaded in the crosslinked micelles with PEG5K as the outer shell exhibit the longest blood circulation after intravenous injection.

Graphical abstract: Reduction-responsive shell-crosslinked micelles prepared from Y-shaped amphiphilic block copolymers as a drug carrier

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Publication details

The article was received on 27 Feb 2012, accepted on 07 May 2012 and first published on 15 Jun 2012


Article type: Paper
DOI: 10.1039/C2SM25456E
Citation: Soft Matter, 2012,8, 7426-7435
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    Reduction-responsive shell-crosslinked micelles prepared from Y-shaped amphiphilic block copolymers as a drug carrier

    J. Yue, R. Wang, S. Liu, S. Wu, Z. Xie, Y. Huang and X. Jing, Soft Matter, 2012, 8, 7426
    DOI: 10.1039/C2SM25456E

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