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Issue 14, 2012
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Surface-adhesive and osteogenic self-assembled peptide nanofibers for bioinspired functionalization of titanium surfaces

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Abstract

Mechanical properties and biological inertness of titanium provide potential in orthopedic and dental implants. However, integration of titanium-based implants into the existing tissue is a major problem. Herein, we demonstrate biofunctionalization of titanium surfaces through a mussel-inspired adhesion mechanism conjugated to self-assembled peptide nanofibers in order to overcome biocompatibility issues. A Dopa conjugated peptide nanofiber coating was used along with bioactive peptide sequences for osteogenic activity to enhance osseointegration of medical grade titanium surface, TiAl6V4 alloy. Dopa-mediated immobilization of osteogenic peptide nanofibers on titanium surfaces created an osteoconductive interface between osteoblast-like cells and inhibited adhesion and viability of soft tissue forming fibroblasts compared to the uncoated titanium substrate. This biofunctionalization strategy can be extended into other surface immobilization systems owing to the versatile adhesive properties of Dopa and the ease of ligand conjugation to peptide amphiphile molecules.

Graphical abstract: Surface-adhesive and osteogenic self-assembled peptide nanofibers for bioinspired functionalization of titanium surfaces

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Publication details

The article was received on 17 Jan 2012, accepted on 03 Feb 2012 and first published on 28 Feb 2012


Article type: Paper
DOI: 10.1039/C2SM25127B
Citation: Soft Matter, 2012,8, 3929-3937
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    Surface-adhesive and osteogenic self-assembled peptide nanofibers for bioinspired functionalization of titanium surfaces

    H. Ceylan, S. Kocabey, A. B. Tekinay and M. O. Guler, Soft Matter, 2012, 8, 3929
    DOI: 10.1039/C2SM25127B

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