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Issue 11, 2012
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Lipid membrane curvature induced by distearoyl phosphatidylinositol 4-phosphate

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Abstract

In this paper we present evidence that phosphatidylinositol 4-phosphate induces curvature in biological membranes. The phase behaviour of mixtures of distearoylphosphatidylinositol 4-phosphate (DSPIP) and dioleoylphosphatidylcholine (DOPC) as a function of pressure and temperature has been studied using small-angle X-ray scattering and in the presence of biologically relevant magnesium concentrations. Our results demonstrate that at physiologically relevant concentrations (2 mol%), DSPIP is capable of inducing the formation of the inverse hexagonal phase (HII) over a wide range of conditions. This result has implications for the structural role of phosphatidylinositol lipidsin vivo.

Graphical abstract: Lipid membrane curvature induced by distearoyl phosphatidylinositol 4-phosphate

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Publication details

The article was received on 13 Dec 2011, accepted on 18 Jan 2012 and first published on 02 Feb 2012


Article type: Paper
DOI: 10.1039/C2SM07358G
Citation: Soft Matter, 2012,8, 3090-3093
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    Lipid membrane curvature induced by distearoyl phosphatidylinositol 4-phosphate

    S. Furse, N. J. Brooks, A. M. Seddon, R. Woscholski, R. H. Templer, E. W. Tate, P. R. J. Gaffney and O. Ces, Soft Matter, 2012, 8, 3090
    DOI: 10.1039/C2SM07358G

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