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Issue 13, 2012
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Electrochemically driven delivery to cells from vesicles embedded in polyelectrolyte multilayers

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Abstract

Calcein was delivered from a functional coating into viable cells on top of it, upon the application of an electrochemical stimulus. The dye was loaded in liposomes stably embedded in a sandwich of polyelectrolyte multilayers. The covering multilayer was optimized with respect to its chemical composition to be resistant to galvanostatic conditions and to allow for cell growth. Additionally, spatial control over the release was achieved by two different patterning methods: (1) coating the indium tin oxide electrode by a micro-patterned insulator and (2) directly patterning the electrode. The release kinetics could be tuned by regulating the current density.

Graphical abstract: Electrochemically driven delivery to cells from vesicles embedded in polyelectrolyte multilayers

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Publication details

The article was received on 30 Nov 2011, accepted on 17 Jan 2012 and first published on 20 Feb 2012


Article type: Paper
DOI: 10.1039/C2SM07272F
Citation: Soft Matter, 2012,8, 3641-3648
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    Electrochemically driven delivery to cells from vesicles embedded in polyelectrolyte multilayers

    N. Graf, A. Tanno, A. Dochter, N. Rothfuchs, J. Vörös and T. Zambelli, Soft Matter, 2012, 8, 3641
    DOI: 10.1039/C2SM07272F

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