We characterized the breaking, buckling and deformation of a liquid marble upon liquid exchange via external inflow and outflow. During liquid addition, the breaking of liquid marbles was affected by the existence of a swirl flow pattern. During liquid removal, the liquid marbles buckled and their morphology was controlled using penetrating pins. During a zero-net-flow perfusion process, the shapes of liquid marbles were controlled by the arrangement of the inlets and outlets.
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