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Issue 25, 2012
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A peptide-based material for therapeutic carbon monoxide delivery

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Abstract

We report on the preparation of the first material for therapeutic delivery of CO. A peptide amphiphile was synthesized with a covalently attached ruthenium tricarbonyl. Self-assembled nanofiber gels containing this peptide spontaneously released CO with prolonged release kinetics compared to soluble CO donors. Oxidatively stressed cardiomyocytes had improved viability when treated with this peptide, demonstrating its potential as a biodegradable gel for localized therapeutic CO delivery.

Graphical abstract: A peptide-based material for therapeutic carbon monoxide delivery

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Publication details

The article was received on 03 Apr 2012, accepted on 09 May 2012 and first published on 24 May 2012


Article type: Communication
DOI: 10.1039/C2SM25785H
Citation: Soft Matter, 2012,8, 6689-6692
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    A peptide-based material for therapeutic carbon monoxide delivery

    J. B. Matson, M. J. Webber, V. K. Tamboli, B. Weber and S. I. Stupp, Soft Matter, 2012, 8, 6689
    DOI: 10.1039/C2SM25785H

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