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Issue 20, 2012
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Controlled wettability, same chemistry: biological activity of plasma-polymerized coatings

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Abstract

Plasma polymerization was used to produce novel nanometric coatings able to direct fibronectin adsorption and cell response. Using ethyl acrylate as a monomer, we obtain coatings whose chemical composition maintains some of the characteristic functionalities of the photo-initiated polymer, while the water contact angle increases monotonically with the duration of the plasma discharge. Enhanced surface mobility of the polymer chains due to a decrease of the thickness of the coating justifies this increase in wettability at lower treatment times. The coatings with higher surface mobility are shown to promote a more active conformation of the adsorbed protein, as proved by binding of the monoclonal antibodies HFN7.1 and mAb1937. Culture of MC3T3-E1 osteoblast-like cells onto the fibronectin-coated substrates further proves that the more mobile surfaces support better initial cell adhesion, even at low fibronectin surface density, as well as stronger cell-mediated fibronectin reorganization.

Graphical abstract: Controlled wettability, same chemistry: biological activity of plasma-polymerized coatings

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Publication details

The article was received on 22 Feb 2012, accepted on 14 Mar 2012 and first published on 13 Apr 2012


Article type: Paper
DOI: 10.1039/C2SM25413A
Citation: Soft Matter, 2012,8, 5575-5584
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    Controlled wettability, same chemistry: biological activity of plasma-polymerized coatings

    M. Cantini, P. Rico, D. Moratal and M. Salmerón-Sánchez, Soft Matter, 2012, 8, 5575
    DOI: 10.1039/C2SM25413A

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