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Issue 30, 2012
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Assembly and stability of α-helical membrane proteins

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Grease to grease – this is how one might begin to describe the tendency of hydrophobic stretches in protein amino acid sequences to form transmembrane domains. While this simple rule contains a lot of truth, the mechanisms of membrane protein folding, the insertion of hydrophobic protein domains into the lipid bilayer, and the apparent existence of highly polar residues in some proteins in the hydrophobic membrane core are subjects of lively debate – an indication that many details remain unresolved. Here, we present a historical survey of recent insights from experiments and computational studies into the rules and mechanisms of α-helical membrane protein assembly and stability.

Graphical abstract: Assembly and stability of α-helical membrane proteins

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The article was received on 21 Feb 2012, accepted on 29 May 2012 and first published on 14 Jun 2012

Article type: Tutorial Review
DOI: 10.1039/C2SM25402F
Citation: Soft Matter, 2012,8, 7742-7752
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    Assembly and stability of α-helical membrane proteins

    M. Heyden, J. A. Freites, M. B. Ulmschneider, S. H. White and D. J. Tobias, Soft Matter, 2012, 8, 7742
    DOI: 10.1039/C2SM25402F

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