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Issue 17, 2012
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Mastered proteolysis of gelatin gel can control delivery kinetics of entrapped large molecules

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Abstract

Biogels are useful reservoirs for molecular delivery as they can entrap a large variety of compounds in their liquid phase. The delivery kinetics of these molecules is dictated by diffusion laws and thus depends on their molecular size. An original strategy to accelerate the release of large molecules from a gelatin gel is here described. The gel solid network is progressively degraded by enzymes which allows for the delivery of large to very large molecules in a well-controlled way. Diffusion by burst is thus made possible even for very large molecules. Finally, a mathematical model is elaborated to predict the diffusion of molecules entrapped inside a gel undergoing a gel–sol transition.

Graphical abstract: Mastered proteolysis of gelatin gel can control delivery kinetics of entrapped large molecules

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Publication details

The article was received on 30 Nov 2011, accepted on 14 Feb 2012 and first published on 13 Mar 2012


Article type: Paper
DOI: 10.1039/C2SM07269F
Citation: Soft Matter, 2012,8, 4750-4755
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    Mastered proteolysis of gelatin gel can control delivery kinetics of entrapped large molecules

    M. Klak, J. Picard, S. Giraudier and V. Larreta-Garde, Soft Matter, 2012, 8, 4750
    DOI: 10.1039/C2SM07269F

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