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Issue 12, 2012
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β-Amino acid containing proteolitically stable dipeptide based hydrogels: encapsulation and sustained release of some important biomolecules at physiological pH and temperature

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Abstract

Two N-terminally protected dipeptides with a β-amino acid residue form hydrogels at physiological pH and temperature. These two hydrogels have been characterized by various techniques including field emission scanning electron microscopic (FE-SEM), atomic force microscopic (AFM), Fourier transformed infrared (FTIR) spectroscopic and rheological studies. Morphological studies using FE-SEM and AFM suggest the formation of three dimensional nanofibrillar network structures, which might be responsible for the entrapment of water molecules to form gels. The FT-IR study in the gel state is in favour of a β-sheet-like conformation in the gel state. A rheological study of these two gels indicates the formation of stiff viscoelastic materials. Interestingly, these two gels are proteolitically stable due to the presence of the non-proteinous, but naturally occurring, β-alanine residue. These gels have been utilized for encapsulation and sustained release of two vitamins (vitamin B2 and vitamin B12) over 3 days at physiological pH (7.46) and temperature (37 °C). This holds future promise for using these gel-based biomaterials for sustained release of drugs and other biomolecules.

Graphical abstract: β-Amino acid containing proteolitically stable dipeptide based hydrogels: encapsulation and sustained release of some important biomolecules at physiological pH and temperature

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Publication details

The article was received on 14 Nov 2011, accepted on 09 Jan 2012 and first published on 13 Feb 2012


Article type: Paper
DOI: 10.1039/C2SM07168A
Citation: Soft Matter, 2012,8, 3380-3386
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    β-Amino acid containing proteolitically stable dipeptide based hydrogels: encapsulation and sustained release of some important biomolecules at physiological pH and temperature

    J. Nanda and A. Banerjee, Soft Matter, 2012, 8, 3380
    DOI: 10.1039/C2SM07168A

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