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Issue 21, 2012
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A three dimensional soft matter cell model for mechanotransduction

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Abstract

An active multiscale three-dimensional (3D) soft matter cell model is developed to study the mechanotransduction of stem cells in an attempt to explain mechanical information exchange between the cells and their extracellular environment. In the proposed soft matter cell model, the cortical actin–myosin flow or the cytoplasmic flow is modeled as an active nematic fluid gel, the cell nucleus is modeled as a hyperelastic medium, and the ligand–receptor interaction between the cell and extracellular matrix is modeled by a coarse-grained molecular adhesive potential. We have implemented the soft matter cell model in a Lagrange type meshfree Galerkin formulation, and we have developed computational algorithms for adhesive contact between the cell and substrate. A comparison study with experimental data has been conducted to validate the parameters of the cell model. By using the soft matter cell model, we have simulated soft adhesive contact/spreading process between the cell and the extracellular substrate. The numerical simulation shows that the cell can sense substrate elasticity in a variety of different ways from cell spreading motion to cell shape and configuration changes.

Graphical abstract: A three dimensional soft matter cell model for mechanotransduction

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Publication details

The article was received on 09 Nov 2011, accepted on 15 Mar 2012 and first published on 13 Apr 2012


Article type: Paper
DOI: 10.1039/C2SM07138J
Citation: Soft Matter, 2012,8, 5765-5776
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    A three dimensional soft matter cell model for mechanotransduction

    X. Zeng and S. Li, Soft Matter, 2012, 8, 5765
    DOI: 10.1039/C2SM07138J

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