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Issue 5, 2012
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Temperature dependent stiffness and visco-elastic behaviour of lipid coated microbubbles using atomic force microscopy

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Abstract

The compression stiffness of a phospholipid microbubble was determined using force-spectroscopy as a function of temperature. The stiffness was found to decrease by approximately a factor of three from ∼0.08 N m−1, at 10 °C, down to ∼0.03 N m−1 at 37 °C. This temperature dependence indicates that the surface tension of lipid coating is the dominant contribution to the microbubble stiffness. The time-dependent material properties, e.g. creep, increased non-linearly with temperature, showing a factor of two increase in creep-displacement, from ∼24 nm, at 10 °C, to 50 nm, at 37 °C. The standard linear solid model was used to extract the visco-elastic parameters and their determination at different temperatures allowed the first determination of the activation energy for creep, for a microbubble, to be determined.

Graphical abstract: Temperature dependent stiffness and visco-elastic behaviour of lipid coated microbubbles using atomic force microscopy

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Publication details

The article was received on 18 Aug 2011, accepted on 30 Sep 2011 and first published on 03 Nov 2011


Article type: Paper
DOI: 10.1039/C1SM06578E
Citation: Soft Matter, 2012,8, 1321-1326
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    Temperature dependent stiffness and visco-elastic behaviour of lipid coated microbubbles using atomic force microscopy

    C. A. Grant, J. E. McKendry and S. D. Evans, Soft Matter, 2012, 8, 1321
    DOI: 10.1039/C1SM06578E

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