Computer simulations of fusion, fission and shape deformation in lipid membranes

Kai Yang; Yu-qiang Ma

doi:10.1039/C1SM05903C

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Soft Matter

Issue 3, 2012

Where physics meets chemistry meets biology for fundamental soft matter research.

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Computer simulations of fusion, fission and shape deformation in lipid membranes

Kai Yang^a and Yu-qiang Ma*^b^a

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Center for Soft Condensed Matter Physics and Interdisciplinary Research, Soochow University, Suzhou, China

National Laboratory of Solid State Microstructures and Department of Physics, Nanjing University, Nanjing, China
E-mail: myqiang@nju.edu.cn

Soft Matter, 2012,8, 606-618

DOI: 10.1039/C1SM05903C
Received 16 May 2011, Accepted 05 Oct 2011
First published online 02 Nov 2011

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Abstract
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Fusion and fission are two kinds of crucial cellular activities related to cell membranes. Therefore, the studies on fusion and fission are particularly important for the understanding of the nature of cell membranes. In this review, the recent studies on fusion, fission and shape deformation in the lipid membrane investigated by computer simulations are presented. Emphases are put on the causes, possible changes on the molecular level and the evolution pathways of fusion and fission processes. Furthermore, the relationship between fission (or fusion) and membrane deformation is also highlighted.

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