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Issue 12, 2012
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Coordination-responsive selenium-containing polymer micelles for controlled drug release

Wei Cao,a  Yang Li,b  Yu Yi,a  Shaobo Ji,a  Lingwu Zeng,a  Zhiwei Sun*c  and  Huaping Xu*a 
Author affiliations

* Corresponding authors

a Key Lab of Organic Optoelectronics & Molecular Engineering, Department of Chemistry, Tsinghua University, Beijing 100084, China
E-mail: xuhuaping@mail.tsinghua.edu.cn
Fax: +86-10 6279 2406
Tel: +86-10 6277 3672

b Department of Toxicology, School of Public Health, Jilin University, Changchun, China

c School of Public Health and Family Medicine, Capital Medical University, Beijing 100069, China
E-mail: zwsun@ccmu.edu.cn

Abstract

A novel coordination-responsive system for the controlled release of doxorubicin was fabricated by complexing platinum cations with selenium-containing polymers. Doxorubicin loaded in the platinum-coordinating micelles can be released in a controlled manner through the competitive coordination of the platinum cations with glutathione. The coordination micelles are quite biocompatible as vehicles of drug delivery, thus opening a new avenue in multidrug systems for cooperative chemotherapy.

Graphical abstract: Coordination-responsive selenium-containing polymer micelles for controlled drug release

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Publication details

The article was received on 07 Jul 2012, accepted on 27 Aug 2012 and first published on 30 Aug 2012


Article type: Edge Article
DOI: 10.1039/C2SC21315J
Citation: Chem. Sci., 2012,3, 3403-3408
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    Coordination-responsive selenium-containing polymer micelles for controlled drug release

    W. Cao, Y. Li, Y. Yi, S. Ji, L. Zeng, Z. Sun and H. Xu, Chem. Sci., 2012, 3, 3403
    DOI: 10.1039/C2SC21315J

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