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Issue 11, 2012
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A copper-catalyzed arylation of tryptamines for the direct synthesis of aryl pyrroloindolines

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Abstract

An operationally simple, copper-catalyzed arylation of N-tosyltryptamines provides direct access to C3-aryl pyrroloindolines. A range of electron-donating and electron-withdrawing substituents is tolerated on both the indole backbone and the aryl electrophile. These reactions occur under ambient temperatures and with equimolar quantities of the coupling partners.

Graphical abstract: A copper-catalyzed arylation of tryptamines for the direct synthesis of aryl pyrroloindolines

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Publication details

The article was received on 09 Jul 2012, accepted on 09 Aug 2012 and first published on 17 Aug 2012


Article type: Edge Article
DOI: 10.1039/C2SC20914D
Citation: Chem. Sci., 2012,3, 3170-3174
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    A copper-catalyzed arylation of tryptamines for the direct synthesis of aryl pyrroloindolines

    M. E. Kieffer, K. V. Chuang and S. E. Reisman, Chem. Sci., 2012, 3, 3170
    DOI: 10.1039/C2SC20914D

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