Issue 12, 2012
From the journal:

Chemical Science

Interaction of spermine-alanine functionalized perylene bisimide dye aggregates with ds-DNA/RNA secondary structure†

Thomas H. Rehm,a   Marijana Radić Stojković,b   Stefanie Rehm,a   Marko Škugor,b   Ivo Piantanida*b  and  Frank Würthner*a  

* Corresponding authors

a Universität Würzburg, Institut für Organische Chemie and Center for Nanosystems Chemistry, Am Hubland, 97074, Würzburg, Germany
E-mail: wuerthner@chemie.uni-wuerzburg.de
Fax: +49 931 31 84756
Tel: +49 931 31 85340

b Rudjer Boskovic Institute, Division of Organic Chemistry & Biochemistry, Bijenicka c. 54, Zagreb, Croatia
E-mail: ivo.piantanida@irb.hr
Fax: +385 1 4680 195

Abstract

We report for the first time on the interaction of self-assembled perylene bisimide (PBI) dye aggregates with polynucleotides, revealing very high (nM) binding constants and exceptional thermal stabilization of double-stranded (ds)-DNA/RNA. Induced CD profiles of PBI dimer aggregates formed within DNA/RNA grooves show high sensitivity on the steric properties of the binding site, suggesting the applicability of such self-adjusting excitonically coupled PBI dimers for the sensing of the DNA/RNA secondary structure.

Graphical abstract: Interaction of spermine-alanine functionalized perylene bisimide dye aggregates with ds-DNA/RNA secondary structure

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Article information

DOI
https://doi.org/10.1039/C2SC20825C
Article type
Edge Article
Submitted
27 Jun 2012
Accepted
23 Aug 2012
First published
24 Aug 2012

Chem. Sci., 2012,3, 3393-3397

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Interaction of spermine-alanine functionalized perylene bisimide dye aggregates with ds-DNA/RNA secondary structure

T. H. Rehm, M. R. Stojković, S. Rehm, M. Škugor, I. Piantanida and F. Würthner, Chem. Sci., 2012, 3, 3393 DOI: 10.1039/C2SC20825C

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