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Issue 10, 2012
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A nanocrystal-based ratiometric pH sensor for natural pH ranges

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Abstract

A ratiometric fluorescent pH sensor based on CdSe/CdZnS nanocrystal quantum dots (NCs) has been designed for biological pH ranges. The construct is formed from the conjugation of a pH dye (SNARF) to NCs coated with a poly(amido amine) (PAMAM) dendrimer. The sensor exhibits a well-resolved ratio response at pH values between 6 and 8 under linear or two-photon excitation, and in the presence of a 4% bovine serum albumin (BSA) solution.

Graphical abstract: A nanocrystal-based ratiometric pH sensor for natural pH ranges

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Publication details

The article was received on 21 Feb 2012, accepted on 22 Jun 2012 and first published on 26 Jun 2012


Article type: Edge Article
DOI: 10.1039/C2SC20212C
Citation: Chem. Sci., 2012,3, 2980-2985
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    A nanocrystal-based ratiometric pH sensor for natural pH ranges

    R. C. Somers, R. M. Lanning, P. T. Snee, A. B. Greytak, R. K. Jain, M. G. Bawendi and D. G. Nocera, Chem. Sci., 2012, 3, 2980
    DOI: 10.1039/C2SC20212C

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