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Issue 6, 2012
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Hydrogenases and oxygen

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Abstract

Hydrogenases represent a heterogeneous group of enzymes consisting of three evolutionary unrelated classes, i.e. [NiFe], [FeFe] and [Fe] hydrogenases. They allow the uni-cellular organisms in which they are expressed to use hydrogen as energy source or to reduce protons as a sink for excess reduction equivalents. Because of this capability there is growing interest in exploiting these enzymes in the field of sustainable energy generation. However, most hydrogenases which are appealing in this context are reversibly or irreversibly inhibited by dioxygen. Here, we summarize the current picture of oxygen-induced inhibition of the different classes of hydrogenases and discuss possible avenues that might lead to tailored oxygen-robust enzyme variants.

Graphical abstract: Hydrogenases and oxygen

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Publication details

The article was received on 23 Dec 2011, accepted on 03 Feb 2012 and first published on 23 Feb 2012


Article type: Perspective
DOI: 10.1039/C2SC01112C
Citation: Chem. Sci., 2012,3, 1739-1751
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    Hydrogenases and oxygen

    M. T. Stiebritz and M. Reiher, Chem. Sci., 2012, 3, 1739
    DOI: 10.1039/C2SC01112C

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