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Issue 4, 2012
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On the rational design of microwave-actuated organic reactions

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Abstract

Microwave-actuated organic reactions are defined herein as chemical reaction systems for which microwave irradiation provides a clear benefit over conventional heating to the same temperature. This study is focused on a rationally designed, microwave-actuated reaction (thermal Friedel–Crafts benzylation), in which a microwave-absorbing ionic solute reacts in a non-polar and largely microwave-transparent solvent. Steady-state microwave irradiation (ssMWi) induces observed levels of reactivity from the solute that cannot be duplicated by conventional heating of the homogeneous solution to similar temperatures. This observation is qualitatively consistent with the Arrhenius [k = Ae(−Ea/RT)] relationship between rate and molecular collisions (kA at constant T). A new paradigm for designing microwave-actuated organic reactions for microwave-assisted organic synthesis emerges from this study.

Graphical abstract: On the rational design of microwave-actuated organic reactions

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Publication details

The article was received on 01 Dec 2011, accepted on 16 Jan 2012 and first published on 17 Jan 2012


Article type: Edge Article
DOI: 10.1039/C2SC01003H
Citation: Chem. Sci., 2012,3, 1240-1244
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    On the rational design of microwave-actuated organic reactions

    M. R. Rosana, Y. Tao, A. E. Stiegman and G. B. Dudley, Chem. Sci., 2012, 3, 1240
    DOI: 10.1039/C2SC01003H

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