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Issue 2, 2012
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A thermally stable {FeNO}8 complex: properties and biological reactivity of reduced MNO systems

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Abstract

Reduced nitrogen oxide ligands such as NO/HNO or nitroxyl participate in chemistry distinct from nitric oxide (NO). Nitroxyl has been proposed to form at heme centers to generate the Enemark–Feltham designated {FeNO}8 system. The synthesis of a thermally stable {FeNO}8 species namely, [Co(Cp*)2][Fe(LN4)(NO)] (3), housed in a heme-like ligand platform has been achieved by reduction of the corresponding {FeNO}7 complex, [Fe(LN4)(NO)] (1), with decamethylcobaltocene [Co(Cp*)2] in toluene. This complex readily reacts with metMb, resulting in formation of MbNO via reductive nitrosylation by the coordinated HNO/NO, which can be inhibited with GSH. These results suggest that 3 could serve as a potential HNO therapeutic. Spectroscopic, theoretical, and structural comparisons are made to 1 and the {CoNO}8 complex, [Co(LN4)(NO)] (2), an isoelectronic analogue of 3.

Graphical abstract: A thermally stable {FeNO}8 complex: properties and biological reactivity of reduced MNO systems

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Publication details

The article was received on 21 Aug 2011, accepted on 13 Sep 2011 and first published on 06 Oct 2011


Article type: Edge Article
DOI: 10.1039/C1SC00582K
Citation: Chem. Sci., 2012,3, 364-369
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    A thermally stable {FeNO}8 complex: properties and biological reactivity of reduced MNO systems

    A. K. Patra, K. S. Dube, B. C. Sanders, G. C. Papaefthymiou, J. Conradie, A. Ghosh and T. C. Harrop, Chem. Sci., 2012, 3, 364
    DOI: 10.1039/C1SC00582K

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